刘学良
Xuelianghc@163.com
教育与工作背景
上海交通大学 2024-至今
副研究员：上海交通大学医学院，仁济医院，分子医学研究院浦南分院
上海交通大学 2021-2024
博士后：上海交通大学医学院，仁济医院，分子医学研究院
指导导师：杨宇研究员
上海交通大学 2016-2021
博士研究生：上海交通大学医学院，基础医学院，药理与化学生物学系
导师：方超教授
山东大学 2012-2016
本科：药学院，天然产物化学生物学教育部重点实验室
指导导师：徐文方教授
研究领域
1. 构建金属DNA纳米组装体作为智能纳米药物来克服生物系统屏障，从而开发肿瘤化疗、光学及免疫治疗新策略。
2. 构建响应和调控肿瘤微环境的新型核酸/纳米药物，实现高效、精准的肿瘤靶向治疗。
发表论文
10. Xueliang Liu#, Fan Li#, Ziliang Dong, Chao Gu, Dongsheng Mao , Jingqi Chen1, Lei Luo, Yuting Huang, Jie Xiao*, Zhanchun Li*, Zhuang Liu*, Yu Yang*. Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment, Science Advances, 2023, 9(31), eadf3329. Highlighted by Nat. Rev. Rheumatol. 2023,19, 606. (IF=13.6)
9. Xueliang Liu#, Binghua Chen#, Jingqi Chen#, Xuan Wang, Xinfeng Dai, Yuqing Li, Huayuan Zhou, Lianming Wu*, Zhuang Liu*, Yu Yang*.A Cardiac-Targeted Nanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial Infarction, Advanced Materials, 2024, 36(2): 2308477. (IF=29.4)
8. Chao Gu#, Xueliang Liu#, Lei Luo, Jingqi Chen, Xiao Zhou, Ganghui Chen, Xin Huang, Lu Yu, Qian Chen, Yu Yang*, and Yang Yang*. Metal-DNA Nanocomplexes Enhance Chemo-dynamic Therapy by Inhibiting Autophagy-Mediated Resistance, Angewandte Chemie International Edition, 2023, 62(50): e202307020. (IF=16.6)
7. Yuqing Li#, Xueliang Liu#, Lu Yu, Xin Huang, Xuan Wang, Da Han*, Yu Yang*, and Zhuang Liu*. Covalent LYTAC Enabled by DNA Aptamers for Immune Checkpoint Degradation Therapy, Journal of the American Chemical Society, 2023,145, 45, 24506–24521. (IF=15.0)
6. Yuting Huang#, Xueliang Liu#, Jiawei Zhu#, Zhejie Chen, Lu Yu, Xin Huang, Chuhuang Dong, Jiabei Li, Huayuan Zhou, Yu Yang*, Weihong Tan1. Enzyme core spherical nucleic acid that enables enhanced cuproptosis and anti-tumor immune response through alleviating tumor hypoxia, Journal of the American Chemical Society, 2024, 146(20):13805-13816. (IF=15.0)
5. Xue-Liang Liu, Xiao Dong, Si-Cong Yang, Xing Lai, Hai-Jun Liu, Yuhao Gao, Hai-Yi Feng, Mao-Hua Zhu, Yihang Yuan, Qin Lu, Jonathan F. Lovell, Hong-Zhuan Chen,* Chao Fang*. Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy. Advanced Science, 2021, 8(8): 2003679. (IF=17.521)
4. Ziyi Gu#, Xueliang Liu#, Zhen Qi, Zhou Fang, Yiting Jiang, Yuting Huang, Yongyi Wang* Lianming Wu*, Yu Yang*. A antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction, Chemical Engineering Journal, 2024. In minor revision. (IF=15.1)
3. Guowang Cheng#, Xueliang Liu#, Yujing Liu, Yao Liu, Rui Ma, Jingshan Luo, Xinyi Zhou, Zhenfeng Wu*, Zhuang Liu, Tongkai Chen*, Yu Yang*. Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson’s Disease. Research, 2022, 9781323. (IF=11.0)
2. Jian Wang#, Jiayi Wang#, Huayuan Zhou, Rui Ma, Zhou Fang, Jiawei Zhu, Zhejie Chen, Xinfeng Dai, Dali Wei, Jiabei Li, Yiting Jiang, Qian Xia*, Xueliang Liu*, Yu Yang*. Universal Antibacterial and Anti-inflammatory Treatment using Chitosan-Prussian Blue Nanozyme, EngMedicine, 2024, 1, 1, 100006.
1. Jiayi Wang#, Jiahua Pan#, Yijun Tang, Jingqi Chen, Xiaochen Fei, Wei Xue* and Xueliang Liu*. Advances of hafnium based nanomaterials for cancer theranostics. Frontiers in Chemistry, 2023, 11: 1283924. (IF=5.5)